Endocrine Abstracts

Introduction: Amiodarone-induced thyrotoxicosis (AIT) can present a high morbi-mortality.Initial subtype identification facilitates appropriate management.We describe the utility of diagnostic tests in a cohort of patients with AIT.Material and methods: Retrospective, observational study of 59 patients attended from 2007 to 2018 in outpatient clinic. Differential diagnosis: type I if FT4 and FT3 (TH) were normalized following therapy with antithyroid dru...

Context: Primary hyperparathyroidism (PHPT) is a common endocrine disease, characterized by the chronic elevation of serum calcium (Ca) levels induced by a long-standing increase of PTH concentrations. PHPT includes mild-asymptomatic and symptomatic forms. Cinacalcet is effective in lowering serum Ca levels in PHPT, but is indicated solely in mild-asymptomatic PHPT meeting surgery criteria. Management of non-surgical mild-asymptomatic PHPT is still a debated issue.<p class...

Introduction: Fatal insomnia is a neurodegenerative spongiform prion disease. Presentation can be sporadic or hereditary (autonomal dominant). The latter, FFI, is caused by a mutation in the human prion protein gene on chromosome 20. Affected individuals present a disorderd sleep-wake cycle, dysautonomia and motor signs, with a predominance of lesions in the thalamus. SIADH has been described in two affected patients.Case Study: A 70-year-old woman was r...